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Dr. Ann B. McCombs, DO

Dr. Ann McCombs DO has a goal to help inform people about a healthcare methodology (non-protocol medicine) to optimize one's physical, emotional, mental, social, environmental and spiritual health, with primary emphasis on treating people individually, including biochemically. Dr. Ann McCombs DO is co-founder and the Medical Director of the Center for Optimal Health at 16236 SE 24th St,  Bellevue, WA 98008 (Tel 425-213-1555; Fax 425-213-1257). Dr. McComb's website is or email .

Dr. McCombs served as a member of the Board of Trustees of the American Holistic Medical Association while currently serving on the Board of Directors for Dr. Devi Nambudripad’s Allergy Research Foundation and Carbon Based Corporation (a company specializing in multi-variate analysis of biochemical tests). She is also co-founder of the American Board of Holistic Medicine and served on the Test Committee and founding Board of Directors. Dr. McCombs holds Post-graduate Certifications in Pain Management, Neural Therapy and Holistic Medicine, Chelation Therapy, Oxidative Medicine, and Heavy Metal Toxology. She was the first certified Neural Therapy Practitioner (including Neural Kinesiology) in the U.S. and is on the faculty of the American Academy of Neural Therapy.

With increasing frequency, conventional and even holistic medical approaches are not meeting the health care needs of many people. Allergies/sensitivities, toxins, infections and/or heavy metals secondary to dental work, are issues in modern medicine today presenting unanswered challenges.

Medical Specialties:

  • Co-founder of the American Board of Holistic Medicine

  • Medical Director of The Center for Optimal Health                                 

  • Post-graduate Certifications in Pain Management, Neural Therapy and Holistic
    Medicine, Chelation Therapy, Oxidative Medicine, and Heavy Metal Toxology

  • Faculty of the American Academy of Neural Therapy. Nambudripad’s Allergy Elimination Technique (N.A.E.T.),

  • Author of The Pillars of Metabolic Health

The Pillars of Metabolic* Health

By Ann McCombs DO with Frank Jordan's Notes and Definitions

1.        Diet: A balanced and healthy diet serves as the backbone in helping to restore the vitamin, mineral and protein deficiencies so commonly seen in the population. Choose organic options as often as possible. In addition, drink “healthy” H20 only, from glass or BPA free containers (FJ: ½ body weight in ounces daily suggested).

2.       Probiotics: Because the health of the gastrointestinal system is crucial to achieve optimal health, the proper balance of “good” bacteria in the intestines plays a major role in promoting complete digestion of foods and minimizing the overgrowth of pathogens. (FJ: 7 to 1 ratio suggested).

3.       Digestive Enzymes: Effective breakdown of carbohydrates, proteins and fats in the diet = optimal digestive function.  Improper breakdown of foods can result in food allergies and nutritional deficiencies. Supplemental enzymes can aid the digestive process to ensure utilization of all the nutrients that are consumed.

4.       B-Vitamins: B-Vitamins are essential for regulating metabolism and allowing normal energy production to occur, including normal amino acid metabolism. Stress can create significant deficiencies of these all-important co-factors, creating a need for increased amounts from time to time.

5.       Trace Minerals: Trace minerals act like enzymes in the body to promote cellular metabolism and support energy production. Without them, the cell cannot utilize amino acids to “turn” the Krebs Cycle** (see notes below) and make ATP (cellular energy) which can result in feelings of fatigue and weakness.

6.       Electrolytes: Electrolytes are minerals in a fluid solution and allow for the normal conduction of electricity in the body.  Minerals that act as electrolytes are magnesium, sodium, phosphorus, potassium, calcium bicarbonate, chloride and sulfate. Electrolytes support amino acid absorption, digestion and proper nerve function.

7.       Amino Acids (AA): AA’s are the building blocks for all cells and result from the breakdown of proteins. Nearly 100 AA’s have been identified; yet only 10 to 14 are considered essential, from which all others can be made. Without an adequate supply of these 10-14, cells cannot repair themselves or generate new cells. Thus, AA’s are critical components of nearly every body function, including detoxification.

8.       Essential Fatty Acids (EFA): The majority of the American diet is filed with Omega-6 and saturated FA’s and lack Omega-3’s.  In order to promote central nervous system function and minimize inflammation in general, supplementation with EFA’s is necessary. A balanced form of Omega 3,6 and 9 EFA’s is the basic formula to correct almost all EFA deficiencies.

9.       Antioxidants: Antioxidants are crucial in helping the body to detoxify and minimizing the damage done by toxins and excessive exercise. Basic antioxidants consist of vitamins A, C, and E and selenium.

Note: While not a metabolic function, the immune response is positively or negatively effected by the pillars of metabolic health and essential to good health and a quality extended life.

Immune Response Normalizers (FJ addition):  Approximately 20% of the body cells involve the immune response to protect what seeks to harm the human body.  Diet, exercise, sleep, stress reduction and supplementation with quality biological defense modifiers such as vitamins A, B6, D3, E, with NAC, CoQ10, MG Beta Glucan and more, contribute to essential immune response normalization and positive metabolic function in the body.

* Metabolism: The sum total of the chemical processes that occur in living cells or organisms that produce substances and energy needed to sustain growth and life. As part of metabolism, organic compounds are broken down to provide heat and energy in the process called catabolism. Simpler molecules are also used to build more complex compounds like proteins for growth and repair of tissues as part of anabolism. Many metabolic processes are brought about by the action of enzymes.
** Krebs cycle
A series of chemical reactions that occur in most aerobic organisms occurring only in the presence of oxygen and are part of the process of aerobic cell metabolism, by which glucose and other molecules are broken down in the presence of oxygen into carbon dioxide and water to release chemical energy in the form of ATP. The Krebs cycle is the intermediate stage, occurring between glycolysis and phosphorylation, and results in the enzymatic breaking down, rearranging, and recombination of byproducts of glycolysis. The combination of glycolysis and the Krebs cycle ultimately allows 36 ATP molecules to be produced from the energy contained in one molecule of glucose and six molecules of oxygen. Also called citric acid cycle. Glycolysis is the metabolic process that breaks down carbohydrates and sugars through a series of reactions to either pyruvic acid or lactic acid and release energy for the body in the form of ATP.

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Last modified: 12/13 /18